Folic acid prevents exencephaly in Cited2 deficient mice

Tongue Abnormalities Are Associated to a Maternal Folic Acid Deficient Diet in Mice

It is widely accepted that maternal folic acid (FA) deficiency during pregnancy is a risk factor for abnormal development. The tongue, with multiple genes working together in a coordinated cascade in time and place, has emerged as a target organ for testing the effect of FA during development. A FA-deficient (FAD) diet was administered to eight-week-old C57/BL/6J mouse females for 2-16 weeks. P...

Folic acid supplementation delays atherosclerotic lesion development in apoE-deficient mice.

Folic acid is a vitamin that when used as a dietary supplementation can improve endothelial function. To assess the effect of folic acid on the development of atherosclerosis, male apolipoprotein E-deficient mice fed a standard chow diet received either water (control group) or an aqueous solution of folic acid that provided a dose of 75 microg/kg/day, for ten weeks. At the time of sacrifice, b...

Folic acid replacement in folate-deficient children on anticonvulsants.

309 infection. Since Case 18 failed to respond adequately to either arginine alone or arginine with oestrogen priming, an insulin response test was performed, and she also failed to respond to this. Discussion The majority of subjects with chromosomal anomalies also have a disorder of growth. Tall stature in males with multiple X chromosome disorders, and short stature in subjects with the XO s...

Normal folic acid metabolism in iron-deficient rats.

I . Weanling rats were fed on an iron-deficient diet without added folic acid and litter-mate controls received the same diet supplemented with Fe. Groups of deficient and control animals were killed at intervals of up to 88 days and glutamate formiminotransferase activity in liver and folic acid activity in liver and serum were measured. 2. No differences were found between the results from th...

Characteristics of folic acid-binding protein in folate-deficient serum.